Control of plant cell fate transitions by transcriptional and hormonal signals

Author:

Gaillochet Christophe1ORCID,Stiehl Thomas23ORCID,Wenzl Christian1,Ripoll Juan-José4ORCID,Bailey-Steinitz Lindsay J4,Li Lanxin1,Pfeiffer Anne1ORCID,Miotk Andrej1ORCID,Hakenjos Jana P1,Forner Joachim1ORCID,Yanofsky Martin F4,Marciniak-Czochra Anna235ORCID,Lohmann Jan U1ORCID

Affiliation:

1. Department of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany

2. Institute of Applied Mathematics, Heidelberg University, Heidelberg, Germany

3. Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany

4. Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, San Diego, United States

5. Bioquant Center, Heidelberg University, Heidelberg, Germany

Abstract

Plant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differentiate. In this study, we used an integrated approach to elucidate the role of HECATE (HEC) genes in regulating developmental trajectories of shoot stem cells in Arabidopsis thaliana. Our work reveals that HEC function stabilizes cell fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem cell differentiation. Importantly, this activity is concomitant with the local modulation of cellular responses to cytokinin and auxin, two key phytohormones regulating cell behaviour. Mechanistically, we show that HEC factors transcriptionally control and physically interact with MONOPTEROS (MP), a key regulator of auxin signalling, and modulate the autocatalytic stabilization of auxin signalling output.

Funder

Deutsche Forschungsgemeinschaft

European Social Fund

Baden-Württemberg Stiftung

National Institutes of Health

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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