Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms-Reference-Cited by-同舟云学术

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Published:2019-09-30 Issue: Volume:8 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Haraguchi Shogo¹²^ORCID,Kamata Masaki¹,Tokita Takuma¹,Tashiro Kei-ichiro¹,Sato Miku¹,Nozaki Mitsuki¹,Okamoto-Katsuyama Mayumi³,Shimizu Isao³,Han Guofeng⁴,Chowdhury Vishwajit Sur⁴,Lei Xiao-Feng²,Miyazaki Takuro²,Kim-Kaneyama Joo-ri²,Nakamachi Tomoya⁵,Matsuda Kouhei⁵^ORCID,Ohtaki Hirokazu⁶,Tokumoto Toshinobu⁷,Tachibana Tetsuya⁸,Miyazaki Akira²,Tsutsui Kazuyoshi¹

Affiliation:

1. Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, Tokyo, Japan

2. Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan

3. Department of Applied Chemistry, School of Science and Engineering, Waseda University, Tokyo, Japan

4. Laboratory of Stress Physiology and Metabolism, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka, Japan

5. Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan

6. Department of Anatomy, Showa University School of Medicine, Tokyo, Japan

7. Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan

8. Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Japan

Abstract

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks.

Funder

Japan Society for the Promotion of Science

Takeda Science Foundation

Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care

Kao Corporation

Naito Foundation

Narishige Zoological Science Foundation

Yamaguchi Endocrine Research Foundation

Suntory Foundation

Publisher

eLife Sciences Publications, Ltd

Subject