Internally generated time in the rodent hippocampus is logarithmically compressed

Author:

Cao Rui1ORCID,Bladon John H2ORCID,Charczynski Stephen J1,Hasselmo Michael E1,Howard Marc W1ORCID

Affiliation:

1. Department of Psychological and Brain Sciences, Boston University

2. Department of Psychology, Brandeis University

Abstract

The Weber-Fechner law proposes that our perceived sensory input increases with physical input on a logarithmic scale. Hippocampal ‘time cells’ carry a record of recent experience by firing sequentially during a circumscribed period of time after a triggering stimulus. Different cells have ‘time fields’ at different delays up to at least tens of seconds. Past studies suggest that time cells represent a compressed timeline by demonstrating that fewer time cells fire late in the delay and their time fields are wider. This paper asks whether the compression of time cells obeys the Weber-Fechner Law. Time cells were studied with a hierarchical Bayesian model that simultaneously accounts for the firing pattern at the trial level, cell level, and population level. This procedure allows separate estimates of the within-trial receptive field width and the across-trial variability. After isolating across-trial variability, time field width increased linearly with delay. Further, the time cell population was distributed evenly along a logarithmic time axis. These findings provide strong quantitative evidence that the neural temporal representation in rodent hippocampus is logarithmically compressed and obeys a neural Weber-Fechner Law.

Funder

Multidisciplinary University Research Initiative

National Institute of Biomedical Imaging and Bioengineering

National Institute of Mental Health

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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