Involvement of superior colliculus in complex figure detection of mice

Author:

Cazemier J Leonie1ORCID,Haak Robin1,Tran TK Loan1,Hsu Ann TY1,Husic Medina1,Peri Brandon D1,Kirchberger Lisa2,Self Matthew W2ORCID,Roelfsema Pieter2345ORCID,Heimel J Alexander1ORCID

Affiliation:

1. Department of Circuits, Structure & Function, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW)

2. Department of Vision and Cognition, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW)

3. Department of Integrative Neurophysiology, VU University

4. Department of Psychiatry, Academic Medical Centre

5. Laboratory of Visual Brain Therapy, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision

Abstract

Object detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been shown that superficial layers of mouse SC (sSC) encode visual features of complex objects, and that this code is not inherited from the primary visual cortex. This suggests that mouse sSC may provide a significant contribution to complex object vision. Here, we use optogenetics to show that mouse sSC is involved in figure detection based on differences in figure contrast, orientation, and phase. Additionally, our neural recordings show that in mouse sSC, image elements that belong to a figure elicit stronger activity than those same elements when they are part of the background. The discriminability of this neural code is higher for correct trials than for incorrect trials. Our results provide new insight into the behavioral relevance of the visual processing that takes place in sSC.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

eLife Sciences Publications, Ltd

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