Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy-Reference-Cited by-同舟云学术

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Published:2024-08-13 Issue: Volume: Page:
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Author:

Reimann Michael W¹^ORCID,Bolanõs-Puchet Sirio¹^ORCID,Courcol Jean-Denis¹^ORCID,Egas Santander Daniela¹^ORCID,Arnaudon Alexis¹^ORCID,Coste Benoît¹,Delalondre Fabien¹,Delemontex Thomas¹^ORCID,Devresse Adrien¹^ORCID,Dictus Hugo¹,Dietz Alexander¹,Ecker András¹^ORCID,Favreau Cyrille¹^ORCID,Ficarelli Gianluca¹^ORCID,Gevaert Mike¹^ORCID,Herttuainen Joni¹^ORCID,Isbister James B¹^ORCID,Kanari Lida¹^ORCID,Keller Daniel¹,King James¹^ORCID,Kumbhar Pramod¹^ORCID,Lapere Samuel¹^ORCID,Lazovskis Jānis²^ORCID,Lu Huanxiang¹^ORCID,Ninin Nicolas¹,Pereira Fernando¹,Planas Judit¹^ORCID,Pokorny Christoph¹^ORCID,Riquelme Juan Luis¹^ORCID,Romani Armando¹^ORCID,Shi Ying¹^ORCID,Smith Jason P³^ORCID,Sood Vishal¹,Srivastava Mohit⁴,Van Geit Werner¹^ORCID,Vanherpe Liesbeth¹^ORCID,Wolf Matthias¹^ORCID,Levi Ran⁵^ORCID,Hess Kathryn⁶^ORCID,Schürmann Felix¹,Muller Eilif B¹^ORCID,Markram Henry¹^ORCID,Ramaswamy Srikanth¹⁷^ORCID

Affiliation:

1. Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL)

2. Riga Business School, Riga Technical University

3. Nottingham Trent University

4. ELKH-University of Debrecen, Neuroscience Research Group

5. University of Aberdeen

6. Laboratory for Topology and Neuroscience (UPHESS), Brain Mind Institute, School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)

7. Neural Circuits Laboratory, Newcastle University

Abstract

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, interregional connectivity. We present a data-driven computational model of the anatomy of non-barrel primary somatosensory cortex of juvenile rat, integrating whole-brain scale data while providing cellular and subcellular specificity. The model consists of 4.2 million morphologically detailed neurons, placed in a digital brain atlas. They are connected by 14.2 billion synapses, comprising local, mid-range and extrinsic connectivity. We delineated the limits of determining connectivity from anatomy, finding that it reproduces targeting by Sst+ neurons, but requires additional specificity to reproduce targeting by PV+ and VIP+ interneurons. Globally, connectivity was characterized by local clusters tied together through hub neurons in layer 5, demonstrating how local and interegional connectivity are complicit, inseparable networks. The model is suitable for simulation-based studies, and a 211,712 neuron subvolume is made openly available to the community.

Publisher

eLife Sciences Publications, Ltd

Link

https://elifesciences.org/reviewed-preprints/99688v1/pdf

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