Electrophysiological dynamics of a triple network model of cognitive control: A multi-experiment replication

Abstract

Dynamic interactions between large-scale brain networks are thought to underpin human cognitive processes, but their underlying electrophysiological dynamics remain unknown. The triple network model, which highlights the salience, default mode, and frontoparietal networks, provides a fundamental framework for understanding these interactions. To unravel the electrophysiological mechanisms underlying these network dynamics, we utilized intracranial EEG recordings from 177 participants across four distinct memory experiments. Our findings revealed a consistent pattern of directed information flow from the anterior insula, a key node of the salience network, to both the default mode and frontoparietal networks. Notably, this pattern of information transmission was observed regardless of the nature of the tasks, whether they involved externally driven stimuli during encoding or internally governed processes during free recall. Moreover, the directed information flow from the anterior insula to the other networks was present irrespective of the activation or suppression states of individual network nodes. Furthermore, we observed a specific suppression of high-gamma power in the posterior cingulate cortex/precuneus node of the default mode network during memory encoding, but not recall, suggesting a task-specific functional down-regulation of this region. Crucially, these results were reliably replicated across all four experiments, underscoring the robustness and generalizability of our findings. Our study significantly advances the understanding of how coordinated neural network interactions underpin cognitive operations and highlights the critical role of the anterior insula in orchestrating the dynamics of large-scale brain networks. These findings have important implications for elucidating the neural basis of cognitive control and its potential disruptions in various neurological and psychiatric disorders.