Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study
Author:
Eyre David W1234ORCID, Lumley Sheila F2, O'Donnell Denise5, Campbell Mark2, Sims Elizabeth2, Lawson Elaine2, Warren Fiona2, James Tim2, Cox Stuart2, Howarth Alison5, Doherty George5, Hatch Stephanie B56, Kavanagh James5, Chau Kevin K5, Fowler Philip W35ORCID, Swann Jeremy5, Volk Denis35, Yang-Turner Fan35, Stoesser Nicole2345ORCID, Matthews Philippa C25, Dudareva Maria2, Davies Timothy2, Shaw Robert H2, Peto Leon2, Downs Louise O2, Vogt Alexander2, Amini Ali25, Young Bernadette C25ORCID, Drennan Philip George2ORCID, Mentzer Alexander J25ORCID, Skelly Donal T27ORCID, Karpe Fredrik38, Neville Matt J38ORCID, Andersson Monique2, Brent Andrew J2, Jones Nicola2, Martins Ferreira Lucas5, Christott Thomas5, Marsden Brian D59ORCID, Hoosdally Sarah35, Cornall Richard5, Crook Derrick W235ORCID, Stuart David I5, Screaton Gavin5, Watson Adam JR10, Taylor Adan10, Chetwynd Alan10, Grassam-Rowe Alexander10, Mighiu Alexandra S10, Livingstone Angus10, Killen Annabel10, Rigler Caitlin10, Harries Callum10, East Cameron10, Lee Charlotte10, Mason Chris JB10, Holland Christian10, Thompson Connor10, Hennesey Conor10, Savva Constantinos10, Kim David S10, Harris Edward WA10, McGivern Euan J10, Qian Evelyn10, Rothwell Evie10, Back Francesca10, Kelly Gabriella10, Watson Gareth10, Howgego Gregory10, Chase Hannah10, Danbury Hannah10, Laurenson-Schafer Hannah10, Ward Harry L10, Hendron Holly10, Vorley Imogen C10, Tol Isabel10, Gunnell James10, Ward Jocelyn LF10, Drake Jonathan10, Wilson Joseph D10, Morton Joshua10, Dequaire Julie10, O'Byrne Katherine10, Motohashi Kenzo10, Harper Kirsty10, Ravi Krupa10, Millar Lancelot J10, Peck Liam J10, Oliver Madeleine10, English Marcus Rex10, Kumarendran Mary10, Wedlich Matthew10, Ambler Olivia10, Deal Oscar T10, Sweeney Owen10, Cowie Philip10, Naudé Rebecca te Water10, Young Rebecca10, Freer Rosie10, Scott Samuel10, Sussmes Samuel10, Peters Sarah10, Pattenden Saxon10, Waite Seren10, Johnson Síle Ann10, Kourdov Stefan10, Santos-Paulo Stephanie10, Dimitrov Stoyan10, Kerneis Sven10, Ahmed-Firani Tariq10, King Thomas B10, Ritter Thomas G10, Foord Thomas H10, De Toledo Zoe10, Christie Thomas10, Gergely Bernadett2, Axten David2, Simons Emma-Jane2, Nevard Heather2, Philips Jane2, Szczurkowska Justyna2, Patel Kaisha2, Smit Kyla2, Warren Laura2, Morgan Lisa2, Smith Lucianne2, Robles Maria2, McKnight Mary2, Luciw Michael2, Gates Michelle2, Sande Nellia2, Turford Rachel2, Ray Roshni2, Rughani Sonam2, Mitchell Tracey2, Bellinger Trisha2, Wharton Vicki2, Justice Anita2, Jesuthasan Gerald2, Wareing Susan2, Huda Mohamad Fadzillah Nurul2, Cann Kathryn2, Kirton Richard2, Sutton Claire2, Salvagno Claudia2, DAmato Gabriella2, Pill Gemma2, Butcher Lisa2, Rylance-Knight Lydia2, Tabirao Merline2, Moroney Ruth2, Wright Sarah2, Peto Timothy EA235, Holthof Bruno2, O'Donnell Anne-Marie2, Ebner Daniel56ORCID, Conlon Christopher P25, Jeffery Katie2, Walker Timothy M2511,
Affiliation:
1. Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom 2. Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom 3. NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom 4. NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at University of Oxford in partnership with Public Health England, Oxford, United Kingdom 5. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom 6. Target Discovery Institute, University of Oxford, Oxford, United Kingdom 7. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom 8. Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom 9. Kennedy Institute of Rheumatology Research, University of Oxford, Oxford, United Kingdom 10. University of Oxford, Oxford, United Kingdom 11. Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam
Abstract
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]).
Funder
UK Government National Institute of Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance Robertson Foundation NIHR Wellcome Trust Medical Research Council Medical Research Foundation Structural Genomics Consortium Kennedy Trust for Rheumatology Research Schmidt Foundation Wellcome Trust Career Development Fellow
Publisher
eLife Sciences Publications, Ltd
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Cited by
194 articles.
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