Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study-Reference-Cited by-同舟云学术

Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Published:2020-08-21 Issue: Volume:9 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Eyre David W¹²³⁴^ORCID,Lumley Sheila F²,O'Donnell Denise⁵,Campbell Mark²,Sims Elizabeth²,Lawson Elaine²,Warren Fiona²,James Tim²,Cox Stuart²,Howarth Alison⁵,Doherty George⁵,Hatch Stephanie B⁵⁶,Kavanagh James⁵,Chau Kevin K⁵,Fowler Philip W³⁵^ORCID,Swann Jeremy⁵,Volk Denis³⁵,Yang-Turner Fan³⁵,Stoesser Nicole²³⁴⁵^ORCID,Matthews Philippa C²⁵,Dudareva Maria²,Davies Timothy²,Shaw Robert H²,Peto Leon²,Downs Louise O²,Vogt Alexander²,Amini Ali²⁵,Young Bernadette C²⁵^ORCID,Drennan Philip George²^ORCID,Mentzer Alexander J²⁵^ORCID,Skelly Donal T²⁷^ORCID,Karpe Fredrik³⁸,Neville Matt J³⁸^ORCID,Andersson Monique²,Brent Andrew J²,Jones Nicola²,Martins Ferreira Lucas⁵,Christott Thomas⁵,Marsden Brian D⁵⁹^ORCID,Hoosdally Sarah³⁵,Cornall Richard⁵,Crook Derrick W²³⁵^ORCID,Stuart David I⁵,Screaton Gavin⁵,Watson Adam JR¹⁰,Taylor Adan¹⁰,Chetwynd Alan¹⁰,Grassam-Rowe Alexander¹⁰,Mighiu Alexandra S¹⁰,Livingstone Angus¹⁰,Killen Annabel¹⁰,Rigler Caitlin¹⁰,Harries Callum¹⁰,East Cameron¹⁰,Lee Charlotte¹⁰,Mason Chris JB¹⁰,Holland Christian¹⁰,Thompson Connor¹⁰,Hennesey Conor¹⁰,Savva Constantinos¹⁰,Kim David S¹⁰,Harris Edward WA¹⁰,McGivern Euan J¹⁰,Qian Evelyn¹⁰,Rothwell Evie¹⁰,Back Francesca¹⁰,Kelly Gabriella¹⁰,Watson Gareth¹⁰,Howgego Gregory¹⁰,Chase Hannah¹⁰,Danbury Hannah¹⁰,Laurenson-Schafer Hannah¹⁰,Ward Harry L¹⁰,Hendron Holly¹⁰,Vorley Imogen C¹⁰,Tol Isabel¹⁰,Gunnell James¹⁰,Ward Jocelyn LF¹⁰,Drake Jonathan¹⁰,Wilson Joseph D¹⁰,Morton Joshua¹⁰,Dequaire Julie¹⁰,O'Byrne Katherine¹⁰,Motohashi Kenzo¹⁰,Harper Kirsty¹⁰,Ravi Krupa¹⁰,Millar Lancelot J¹⁰,Peck Liam J¹⁰,Oliver Madeleine¹⁰,English Marcus Rex¹⁰,Kumarendran Mary¹⁰,Wedlich Matthew¹⁰,Ambler Olivia¹⁰,Deal Oscar T¹⁰,Sweeney Owen¹⁰,Cowie Philip¹⁰,Naudé Rebecca te Water¹⁰,Young Rebecca¹⁰,Freer Rosie¹⁰,Scott Samuel¹⁰,Sussmes Samuel¹⁰,Peters Sarah¹⁰,Pattenden Saxon¹⁰,Waite Seren¹⁰,Johnson Síle Ann¹⁰,Kourdov Stefan¹⁰,Santos-Paulo Stephanie¹⁰,Dimitrov Stoyan¹⁰,Kerneis Sven¹⁰,Ahmed-Firani Tariq¹⁰,King Thomas B¹⁰,Ritter Thomas G¹⁰,Foord Thomas H¹⁰,De Toledo Zoe¹⁰,Christie Thomas¹⁰,Gergely Bernadett²,Axten David²,Simons Emma-Jane²,Nevard Heather²,Philips Jane²,Szczurkowska Justyna²,Patel Kaisha²,Smit Kyla²,Warren Laura²,Morgan Lisa²,Smith Lucianne²,Robles Maria²,McKnight Mary²,Luciw Michael²,Gates Michelle²,Sande Nellia²,Turford Rachel²,Ray Roshni²,Rughani Sonam²,Mitchell Tracey²,Bellinger Trisha²,Wharton Vicki²,Justice Anita²,Jesuthasan Gerald²,Wareing Susan²,Huda Mohamad Fadzillah Nurul²,Cann Kathryn²,Kirton Richard²,Sutton Claire²,Salvagno Claudia²,DAmato Gabriella²,Pill Gemma²,Butcher Lisa²,Rylance-Knight Lydia²,Tabirao Merline²,Moroney Ruth²,Wright Sarah²,Peto Timothy EA²³⁵,Holthof Bruno²,O'Donnell Anne-Marie²,Ebner Daniel⁵⁶^ORCID,Conlon Christopher P²⁵,Jeffery Katie²,Walker Timothy M²⁵¹¹,

Affiliation:

1. Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

2. Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

3. NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom

4. NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at University of Oxford in partnership with Public Health England, Oxford, United Kingdom

5. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

6. Target Discovery Institute, University of Oxford, Oxford, United Kingdom

7. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

8. Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

9. Kennedy Institute of Rheumatology Research, University of Oxford, Oxford, United Kingdom

10. University of Oxford, Oxford, United Kingdom

11. Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam

Abstract

We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]).

Funder

UK Government

National Institute of Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance

Robertson Foundation

NIHR

Wellcome Trust

Medical Research Council

Medical Research Foundation

Structural Genomics Consortium

Kennedy Trust for Rheumatology Research

Schmidt Foundation

Wellcome Trust Career Development Fellow