Dissociated sequential activity and stimulus encoding in the dorsomedial striatum during spatial working memory

Author:

Akhlaghpour Hessameddin1,Wiskerke Joost12,Choi Jung Yoon12,Taliaferro Joshua P1ORCID,Au Jennifer1,Witten Ilana B12ORCID

Affiliation:

1. Princeton Neuroscience Institute, Princeton University, Princeton, United States

2. Department of Psychology, Princeton University, Princeton, United States

Abstract

Several lines of evidence suggest that the striatum has an important role in spatial working memory. The neural dynamics in the striatum have been described in tasks with short delay periods (1–4 s), but remain largely uncharacterized for tasks with longer delay periods. We collected and analyzed single unit recordings from the dorsomedial striatum of rats performing a spatial working memory task with delays up to 10 s. We found that neurons were activated sequentially, with the sequences spanning the entire delay period. Surprisingly, this sequential activity was dissociated from stimulus encoding activity, which was present in the same neurons, but preferentially appeared towards the onset of the delay period. These observations contrast with descriptions of sequential dynamics during similar tasks in other brains areas, and clarify the contribution of the striatum to spatial working memory.

Funder

National Science Foundation

National Institute of Mental Health

McKnight Foundation

Pew Charitable Trusts

National Institutes of Health

National Alliance for Research on Schizophrenia and Depression

Alfred P. Sloan Foundation

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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