Affiliation:
1. Volen Center and Biology Department, Brandeis University, Waltham, United States
2. Grass Laboratory, Marine Biological Laboratories, Woods Hole, United States
Abstract
It is often assumed that highly-branched neuronal structures perform
compartmentalized computations. However, previously we showed that the
Gastric Mill (GM) neuron in the crustacean stomatogastric ganglion (STG)
operates like a single electrotonic compartment, despite having thousands of
branch points and total cable length >10 mm (Otopalik et al., 2017a;
2017b). Here we show that compact electrotonic architecture is generalizable
to other STG neuron types, and that these neurons present
direction-insensitive, linear voltage integration, suggesting they pool
synaptic inputs across their neuronal structures. We also show, using
simulations of 720 cable models spanning a broad range of geometries and
passive properties, that compact electrotonus, linear integration, and
directional insensitivity in STG neurons arise from their neurite geometries
(diameters tapering from 10-20 µm to < 2 µm at their terminal tips). A
broad parameter search reveals multiple morphological and biophysical
solutions for achieving different degrees of passive electrotonic decrement
and computational strategies in the absence of active properties.
Funder
National
Institute of Neurological Disorders and Stroke
Grass
Foundation
Publisher
eLife Sciences Publications, Ltd
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Cited by
19 articles.
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