Anosognosia for hemiplegia as a tripartite disconnection syndrome-Reference-Cited by-同舟云学术

Anosognosia for hemiplegia as a tripartite disconnection syndrome

Published:2019-08-06 Issue: Volume:8 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Pacella Valentina¹²,Foulon Chris³⁴⁵^ORCID,Jenkinson Paul M⁶,Scandola Michele²,Bertagnoli Sara²,Avesani Renato⁷,Fotopoulou Aikaterini⁸,Moro Valentina²,Thiebaut de Schotten Michel³⁴⁹^ORCID

Affiliation:

1. Social and Cognitive Neuroscience Laboratory, Department of Psychology, Sapienza University of Rome, Rome, Italy

2. NPSY.Lab-VR, Department of Human Sciences, University of Verona, Verona, Italy

3. Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France

4. Frontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France

5. Computational Neuroimaging Laboratory, Department of Diagnostic Medicine, The University of Texas at Austin Dell Medical School, Austin, United States

6. School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom

7. Department of Rehabilitation, IRCSS Sacro Cuore-Don Calabria Hospital, Verona, Italy

8. Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, United Kingdom

9. Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France

Abstract

The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.

Funder

Horizon 2020 Framework Programme

Ministry of Education, Universities and Research

University of Verona

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/46075/elife-46075-v1.pdf

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