The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled

Author:

Gupta Tripti1234,Kumar Arun1234,Cattenoz Pierre B.1234,VijayRaghavan K56ORCID,Giangrande Angela1234ORCID

Affiliation:

1. Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France

2. Centre National de la Recherche Scientifique, UMR7104, Illkirch, France

3. Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France

4. Université de Strasbourg, Illkirch, France

5. Department of Developmental Biology and Genetics, Tata Institute for Fundamental Research, Bangalore, India

6. National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, India

Abstract

Collective migration is a complex process that contributes to build precise tissue and organ architecture. Several molecules implicated in cell interactions also control collective migration, but their precise role and the finely tuned expression that orchestrates this complex developmental process are poorly understood. Here, we show that the timely and threshold expression of the Netrin receptor Frazzled triggers the initiation of glia migration in the developing Drosophila wing. Frazzled expression is induced by the transcription factor Glide/Gcm in a dose-dependent manner. Thus, the glial determinant also regulates the efficiency of collective migration. NetrinB but not NetrinA serves as a chemoattractant and Unc5 contributes as a repellant Netrin receptor for glia migration. Our model includes strict spatial localization of a ligand, a cell autonomously acting receptor and a fate determinant that act coordinately to direct glia toward their final destination.

Funder

CEFIPRA-4403-1

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

ARC Centre of Excellence for Coherent X-Ray Science

Ligue Contre le Cancer

USIAS

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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