Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners-Reference-Cited by-同舟云学术

Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners

Published:2020-05-05 Issue: Volume:9 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Tunbak Hande¹^ORCID,Vazquez-Prada Mireya¹^ORCID,Ryan Thomas Michael¹^ORCID,Kampff Adam Raymond²^ORCID,Dreosti Elena¹^ORCID

Affiliation:

1. The Wolfson Institute for Biomedical Research, University Street, University College London, London, United Kingdom

2. Sainsbury Wellcome Centre, Howland Street, University College London, London, United Kingdom

Abstract

The zebrafish was used to assess the impact of social isolation on behaviour and brain function. As in humans and other social species, early social deprivation reduced social preference in juvenile zebrafish. Whole-brain functional maps of anti-social isolated (lonely) fish were distinct from anti-social (loner) fish found in the normal population. These isolation-induced activity changes revealed profound disruption of neural activity in brain areas linked to social behaviour, social cue processing, and anxiety/stress. Several of the affected regions are modulated by serotonin, and we found that social preference in isolated fish could be rescued by acutely reducing serotonin levels.

Funder

Wellcome

Gatsby Charitable Foundation

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/55863/elife-55863-v2.pdf

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