Evaluating distributional regression strategies for modelling self-reported sexual age-mixing

Author:

Wolock Timothy M1ORCID,Flaxman Seth1ORCID,Risher Kathryn A23ORCID,Dadirai Tawanda4,Gregson Simon24ORCID,Eaton Jeffrey W2ORCID

Affiliation:

1. Department of Mathematics, Imperial College London, London, United Kingdom

2. MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom

3. London School of Hygiene & Tropical Medicine, London, United Kingdom

4. Manicaland Centre for Public Health Research, Biomedical Research and Training Institute, Harare, Zimbabwe

Abstract

The age dynamics of sexual partnership formation determine patterns of sexually transmitted disease transmission and have long been a focus of researchers studying human immunodeficiency virus. Data on self-reported sexual partner age distributions are available from a variety of sources. We sought to explore statistical models that accurately predict the distribution of sexual partner ages over age and sex. We identified which probability distributions and outcome specifications best captured variation in partner age and quantified the benefits of modelling these data using distributional regression. We found that distributional regression with a sinh-arcsinh distribution replicated observed partner age distributions most accurately across three geographically diverse data sets. This framework can be extended with well-known hierarchical modelling tools and can help improve estimates of sexual age-mixing dynamics.

Funder

Bill and Melinda Gates Foundation

Medical Research Council

National Institute of Allergy and Infectious Diseases

Engineering and Physical Sciences Research Council

Imperial College London

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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