Characterizing causality in cancer-Reference-Cited by-同舟云学术

Characterizing causality in cancer

Published:2019-11-29 Issue: Volume:8 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Rondeau Elena¹²,Larmonier Nicolas¹²,Pradeu Thomas¹²³^ORCID,Bikfalvi Andreas¹³⁴^ORCID

Affiliation:

1. University of Bordeaux, Bordeaux, France

2. ImmunoConcept, CNRS UMR 5164, Bordeaux, France

3. IHPST, CNRS UMR 8590, Paris, France

4. LAMC-INSERM U1029, Bordeaux, France

Abstract

Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/53755/elife-53755-v1.pdf

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