High Frequency Terahertz Stimulation Alleviates Neuropathic Pain by Inhibiting the Pyramidal Neuron Activity in the Anterior Cingulate Cortex of mice

Author:

Peng Wenyu1,Wang Pan2,Tan Chaoyang2,Zhao Han2,Chen Kun2,Si Huaxing2,Tian Yuchen1,Lou Anxin2,Zhu Zhi3,Yuan Yifang4,Wu Kaijie56,Chang Chao47,Wu Yuanming1,Chen Tao2ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University

2. Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, The Fourth Military Medical University

3. Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology

4. Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology

5. Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University

6. School of Electronic and Information Engineering, Anhui University

7. School of Physics, Peking University

Abstract

Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory system and is characterized by abnormal hypersensitivity to stimuli and nociceptive responses to non-noxious stimuli, affecting approximately 7–10% of the general population. However, current first-line drugs like non-steroidal anti-inflammatory agents and opioids have limitations, including dose-limiting side effects, dependence, and tolerability issues. Therefore, developing new interventions for the management of NP is urgent. In this study, we discovered that the high-frequency terahertz stimulation (HFTS) at approximate 36 THz effectively alleviates NP symptoms in mice with spared nerve injury. Computational simulation suggests that the frequency resonates with the carbonyl group in the filter region of Kv1.2 channels, facilitating the translocation of potassium ions. In vivo and in vitro results demonstrate that HFTS reduces the excitability of pyramidal neurons in the anterior cingulate cortex through enhancing the voltage-gated K + and also the leak K + conductance. This research presents a novel optical intervention strategy with terahertz waves for the treatment of NP and holds promising application in other nervous system diseases.

Publisher

eLife Sciences Publications, Ltd

Reference55 articles.

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