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Restricting the sizes of condensates

Published:2020-07-14 Issue: Volume:9 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Dar Furqan¹²^ORCID,Pappu Rohit²³^ORCID

Affiliation:

1. Department of Physics, Washington University in St. Louis, St. Louis, United States

2. Center for Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, United States

3. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, United States

Abstract

Computer simulations of model proteins with sticker-and-spacer architectures shed light on the formation of biomolecular condensates in cells.

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/59663/elife-59663-v1.pdf

Reference12 articles.

1. Biomolecular condensates: organizers of cellular biochemistry;Banani;Nature Reviews Molecular Cell Biology,2017

2. Physical principles of intracellular organization via active and passive phase transitions;Berry;Reports on Progress in Physics,2018

3. Germline P granules are liquid droplets that localize by controlled dissolution/condensation;Brangwynne;Science,2009

4. LASSI: a lattice model for simulating phase transitions of multivalent proteins;Choi;PLOS Computational Biology,2019

5. Physical principles underlying the complex biology of intracellular phase transitions;Choi;Annual Review of Biophysics,2020

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