Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19
Author:
Jones Nick K1234ORCID, Rivett Lucy12, Sparkes Dominic12, Forrest Sally34, Sridhar Sushmita345ORCID, Young Jamie6, Pereira-Dias Joana34, Cormie Claire34, Gill Harmeet34, Reynolds Nicola7, Wantoch Michelle89, Routledge Matthew12, Warne Ben14, Levy Jack10, Córdova Jiménez William David10, Samad Fathima Nisha Begum10, McNicholas Chris11, Ferris Mark12, Gray Jane13, Gill Michael13, Baker Stephen, Bradley John, Dougan Gordon, Goodfellow Ian, Gupta Ravi, Lehner Paul J, Lyons Paul A, Matheson Nicholas J, Smith Kenneth GC, Torok M Estee, Toshner Mark, Weekes Michael P, Jones Nicholas K, Rivett Lucy, Routledge Matthew, Sparkes Dominic, Warne Ben, Cormie Claire, Forrest Sally, Gill Harmeet, Kean Iain, Pereira-Dias Joana, Reynolds Nicola, Sridhar Sushmita, Wantoch Michelle, Young Jamie, Caddy Sarah, Caller Laura, Feltwell Theresa, Hall Grant, Hamilton William, Hosmillo Myra, Houldcroft Charlotte, Jahun Aminu, Khokhar Fahad, Meredith Luke, Yakovleva Anna, Butcher Helen, Caputo Daniela, Clapham-Riley Debra, Dolling Helen, Furlong Anita, Graves Barbara, Le Gresley Emma, Kingston Nathalie, Papadia Sofia, Stark Hannah, Stirrups Kathleen E, Webster Jennifer, Calder Joanna, Harris Julie, Hewitt Sarah, Kennet Jane, Meadows Anne, Rastall Rebecca, Brien Criona O, Price Jo, Publico Cherry, Rowlands Jane, Ruffolo Valentina, Tordesillas Hugo, Gill Michael, Gray Jane, Hannon Greg, Brookes Karen, Canna Laura, Cruz Isabel, Dempsey Katie, Elmer Anne, Escoffery Naidine, Fuller Stewart, Jones Heather, Ribeiro Carla, Saunders Caroline, Wright Angela, Nyagumbo Rutendo, Roberts Anne, Bucke Ashlea, Hargreaves Simone, Johnson Danielle, Narcorda Aileen, Read Debbie, Sparke Christian, Worboys Lucy, Lagadu Kirsty, Mactavous Lenette, Gould Tim, Raine Tim, Shaw Ashley, Mather Claire, Ramenatte Nicola, Vallier Anne-Laure, Kasanicki Mary, Eames Penelope-Jane, McNicholas Chris, Thake Lisa, Bartholomew Neil, Brown Nick, Curran Martin, Parmar Surendra, Zhang Hongyi, Bowring Ailsa, Ferris Mark, Martell Geraldine, Quinnell Natalie, Wright Giles, Wright Jo, Murphy Helen, Dunmore Benjamin J, Legchenko Ekaterina, Gräf Stefan, Huang Christopher, Hodgson Josh, Hunter Kelvin, Martin Jennifer, Mescia Federica, ODonnell Ciara, Pointon Linda, Shih Joy, Sutcliffe Rachel, Tilly Tobias, Tong Zhen, Treacy Carmen, Wood Jennifer, Bergamaschi Laura, Betancourt Ariana, Bowyer Georgie, De Sa Aloka, Epping Maddie, Hinch Andrew, Huhn Oisin, Jarvis Isobel, Lewis Daniel, Marsden Joe, McCallum Simon, Nice Francescsa, Omarjee Ommar, Perera Marianne, Romashova Nika, Strezlecki Mateusz, Yarkoni Natalia Savoinykh, Turner Lori, Bailey Barrie, Chaudhry Afzal, Doughton Rachel, Workman Chris, Trotter Caroline, David William, Jiménez Cordova, Levy Jack, Samad Fatima NB, Curran Martin D2, Fuller Stewart14, Chaudhry Afzal15, Shaw Ashley15, Bradley John R316, Hannon Gregory J13ORCID, Goodfellow Ian G17ORCID, Dougan Gordon34, Smith Kenneth GC34, Lehner Paul J134ORCID, Wright Giles12, Matheson Nicholas J1418ORCID, Baker Stephen34, Weekes Michael P134ORCID,
Affiliation:
1. Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom 2. Clinical Microbiology & Public Health Laboratory, Public Health England, Cambridge, United Kingdom 3. Department of Medicine, University of Cambridge, Cambridge, United Kingdom 4. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom 5. Wellcome Sanger Institute, Hinxton, United Kingdom 6. Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom 7. Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom 8. Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom 9. Department of Haematology, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom 10. Institute for Manufacturing, Department of Engineering, University of Cambridge, Cambridge, United Kingdom 11. Improvement and Transformation Team, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom 12. Occupational Health and Wellbeing, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom 13. Cancer Research United Kingdom Cambridge Institute, University of Cambridge, Cambridge, United Kingdom 14. National Institutes for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom 15. Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom 16. National Institutes for Health Research Cambridge, Clinical Research Facility, Cambridge, United Kingdom 17. Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom 18. NHS Blood and Transplant, Cambridge, United Kingdom
Abstract
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to near-zero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK ‘lockdown’. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent ‘hubs’ of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.
Funder
Wellcome Medical Research Council Addenbrooke's Charitable Trust, Cambridge University Hospitals NHS Blood and Transplant National Institute for Health Research Cancer Research UK
Publisher
eLife Sciences Publications, Ltd
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Cited by
40 articles.
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