Neuro-evolutionary evidence for a universal fractal primate brain shape

Abstract

The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primate cortices. We show that all cortical shapes can be described as a set of nested folds of different sizes. As neighbouring folds are gradually merged, the cortices of 11 primate species follow a common scalefree morphometric trajectory, that also overlaps with over 70 other mammalian species. Our results indicate that all cerebral cortices are approximations of the same archetypal fractal shape with a fractal dimension of d f = 2.5. Importantly, this new understanding enables a more precise quantification of brain morphology as a function of scale. To demonstrate the importance of this new understanding, we show a scale-dependent effect of ageing on brain morphology. We observe a more than four-fold increase in effect size (from 2 standard deviations to 8 standard deviations) at a spatial scale of approximately 2 mm compared to standard morphological analyses. Our new understanding may therefore generate superior biomarkers for a range of conditions in the future.