Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex

Author:

van der Goes Marie-Sophie H1ORCID,Voigts Jakob123,Newman Jonathan P24ORCID,Toloza Enrique HS156,Brown Norma J1,Murugan Pranav7,Harnett Mark T1ORCID

Affiliation:

1. Department of Brain & Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology

2. Open-Ephys Inc

3. HHMI Janelia Research Campus

4. Department of Brain & Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology

5. Department of Physics, Massachusetts Institute of Technology

6. Harvard Medical School

7. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology

Abstract

The sense of direction is critical for survival in changing environments and relies on flexibly integrating self-motion signals with external sensory cues. While the anatomical substrates involved in head direction (HD) coding are well known, the mechanisms by which visual information updates HD representations remain poorly understood. Retrosplenial cortex (RSC) plays a key role in forming coherent representations of space in mammals and it encodes a variety of navigational variables, including HD. Here, we use simultaneous two-area tetrode recording to show that RSC HD representation is nearly synchronous with that of the anterodorsal nucleus of thalamus (ADn), the obligatory thalamic relay of HD to cortex, during rotation of a prominent visual cue. Moreover, coordination of HD representations in the two regions is maintained during darkness. We further show that anatomical and functional connectivity are consistent with a strong feedforward drive of HD information from ADn to RSC, with anatomically restricted corticothalamic feedback. Together, our results indicate a concerted global HD reference update across cortex and thalamus.

Funder

National Institutes of Health

Massachusetts Institute of Technology

Esther A. and Joseph Klingenstein Fund

Publisher

eLife Sciences Publications, Ltd

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