Impaired voice processing in reward and salience circuits predicts social communication in children with autism

Author:

Abrams Daniel Arthur1ORCID,Padmanabhan Aarthi1ORCID,Chen Tianwen1,Odriozola Paola1ORCID,Baker Amanda E1ORCID,Kochalka John1,Phillips Jennifer M1ORCID,Menon Vinod23

Affiliation:

1. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, United States

2. Program in Neuroscience, Stanford University School of Medicine, Stanford, United States

3. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, United States

Abstract

Engaging with vocal sounds is critical for children’s social-emotional learning, and children with autism spectrum disorder (ASD) often ‘tune out’ voices in their environment. Little is known regarding the neurobiological basis of voice processing and its link to social impairments in ASD. Here, we perform the first comprehensive brain network analysis of voice processing in children with ASD. We examined neural responses elicited by unfamiliar voices and mother’s voice, a biologically salient voice for social learning, and identified a striking relationship between social communication abilities in children with ASD and activation in key structures of reward and salience processing regions. Functional connectivity between voice-selective and reward regions during voice processing predicted social communication in children with ASD and distinguished them from typically developing children. Results support the Social Motivation Theory of ASD by showing reward system deficits associated with the processing of a critical social stimulus, mother’s voice, in children with ASD.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that minor issues remain unresolved (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).

Funder

National Institute of Mental Health

Brain and Behavior Research Foundation

Stanford School of Medicine, Stanford Medicine, Stanford University

National Center for Advancing Translational Sciences

National Institute on Deafness and Other Communication Disorders

Singer Family Foundation

Simons Foundation

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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