Rat behavior and dopamine release are modulated by conspecific distress

Author:

Lichtenberg Nina T1,Lee Brian1,Kashtelyan Vadim1,Chappa Bharadwaja S2,Girma Henok T2,Green Elizabeth A2,Kantor Shir2,Lagowala Dave A2,Myers Matthew A2,Potemri Danielle2,Pecukonis Meredith G2,Tesfay Robel T2,Walters Michael S2,Zhao Adam C1,Blair R James R3,Cheer Joseph F456,Roesch Matthew R127ORCID

Affiliation:

1. Department of Psychology, University of Maryland, College Park, United States

2. Gemstone Honors Program, University of Maryland, College Park, United States

3. Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, United States

4. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, United States

5. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, United States

6. Program in Neuroscience, University of Maryland School of Medicine, Baltimore, United States

7. Program in Neuroscience and Cognitive Science, University of Maryland, College Park, United States

Abstract

Rats exhibit ‘empathy’ making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA release in two paradigms: one that involved cues predictive of unavoidable shock to the conspecific and another that allowed the rat to refrain from reward when there were harmful consequences to the conspecific. Behavior and DA reflected pro-social interactions in that DA suppression was reduced during cues that predicted shock in the presence of the conspecific and that DA release observed on self-avoidance trials was present when the conspecific was spared. However, DA also increased when the conspecific was shocked instead of the recording rat and DA release during conspecific avoidance trials was lower than when the rat avoided shock for itself.

Funder

National Institute of Mental Health

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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