Wnt Signaling Regulation in Bone of Postmenopausal Women With Type 2 Diabetes-Reference-Cited by-同舟云学术

Wnt Signaling Regulation in Bone of Postmenopausal Women With Type 2 Diabetes

Published:2023-10-19 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Leanza Giulia¹²^ORCID,Cannata Francesca¹,Faraj Malak¹,Pedone Claudio³,Viola Viola¹,Tramontana Flavia¹²,Pellegrini Niccolò¹,Vadalà Gianluca⁴,Piccoli Alessandra¹,Strollo Rocky⁵,Beeve Alec⁶,Scheller Erica L⁶^ORCID,Tang Simon⁷^ORCID,Civitelli Roberto⁶^ORCID,Maccarrone Mauro⁸⁹,Papalia Rocco⁴,Napoli Nicola¹²⁶

Affiliation:

1. Department of Medicine and Surgery, Research Unit of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy

2. Operative Research Unit of Osteometabolic and Thyroid Diseases, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200 – 00128, Roma, Italy

3. Operative Research Unit of Geriatrics, Fondazione Policlinico Universitario Campus Bio- Medico, Via Alvaro del Portillo, 200 – 00128, Roma, Italy

4. Operative Research Unit of Orthopedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200 – 00128, Roma, Italy

5. Department of Human Sciences and Promotion of the Quality of Life San Raffaele Roma Open University Via di Val Cannuta 247, 00166 Roma, Italy

6. Department of Medicine, Division of Bone and Mineral Diseases. Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO USA

7. Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA

8. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Via Vetoio snc, 67100 L’Aquila, Italy

9. European Center for Brain Research, Santa Lucia Foundation IRCCS, 00164 Roma, Italy

Abstract

Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that bone formation genes (SOST and RUNX2) and advanced glycation end-products (AGEs) were impaired in T2D. Thus, we investigated Wnt signaling regulation and its association with AGEs accumulation in T2D. We obtained bone tissue from 15 T2D and 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend of low mineralized volume in T2D. We showed that gene expression of Wnt agonists LEF-1 and WNT10B were lower in T2D. Accordingly, WNT5A and SOST gene expression were higher, while collagen (COL1A1) was lower in T2D. Importantly, AGEs content was associated with SOST and WNT5A, but inversely correlated with LEF-1 and COL1A1. Finally, SOST was also associated with glycemic control and disease duration. These findings suggest that Wnt signaling and AGEs could be the main determinants of bone fragility in T2D.

Publisher

eLife Sciences Publications, Ltd

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A map of glycation and glycoxidation sites in collagen I of human cortical bone: Effects of sex and type 2 diabetes;Bone;2024-10

2. The causal relationship between metformin and bone mineral density: A Two- Sample Mendelian randomization study;2024-08-16

3. PTH receptor signalling, osteocytes and bone disease induced by diabetes mellitus;Nature Reviews Endocrinology;2024-07-17

4. Bone microarchitecture and strength assessed by HRpQCT in individuals with type 2 diabetes and prediabetes: the Maastricht study;JBMR Plus;2024-07-03