Pupil diameter is not an accurate real-time readout of locus coeruleus activity

Author:

Megemont Marine1,McBurney-Lin Jim12,Yang Hongdian12ORCID

Affiliation:

1. Department of Molecular, Cell and Systems Biology, University of California, Riverside

2. Neuroscience Graduate Program, University of California, Riverside

Abstract

Pupil diameter is often treated as a noninvasive readout of activity in the locus coeruleus (LC). However, how accurately it can be used to index LC activity is not known. To address this question, we established a graded relationship between pupil size changes and LC spiking activity in mice, where pupil dilation increased monotonically with the number of LC spikes. However, this relationship exists with substantial variability such that pupil diameter can only be used to accurately predict a small fraction of LC activity on a moment-by-moment basis. In addition, pupil exhibited large session-to-session fluctuations in response to identical optical stimulation in the LC. The variations in the pupil–LC relationship were strongly correlated with decision bias-related behavioral variables. Together, our data show that substantial variability exists in an overall graded relationship between pupil diameter and LC activity, and further suggest that the pupil–LC relationship is dynamically modulated by brain states, supporting and extending our previous findings (Yang et al., 2021).

Funder

National Institute of Neurological Disorders and Stroke

University of California, Riverside

University of California

Esther A and Joseph Klingenstein Fund

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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