Magnetic stimulation allows focal activation of the mouse cochlea

Author:

Lee Jae-Ik1ORCID,Seist Richard23ORCID,McInturff Stephen24,Lee Daniel J24ORCID,Brown M Christian24ORCID,Stankovic Konstantina M245ORCID,Fried Shelley16ORCID

Affiliation:

1. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School

2. Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School

3. Department of Otorhinolaryngology - Head and Neck Surgery, Paracelsus Medical University

4. Program in Speech and Hearing Bioscience and Technology, Harvard Medical School

5. Department of Otolaryngology – Head and Neck Surgery, Stanford University School of Medicine

6. Boston VA Medical Center

Abstract

Cochlear implants (CIs) provide sound and speech sensations for patients with severe to profound hearing loss by electrically stimulating the auditory nerve. While most CI users achieve some degree of open set word recognition under quiet conditions, hearing that utilizes complex neural coding (e.g., appreciating music) has proved elusive, probably because of the inability of CIs to create narrow regions of spectral activation. Several novel approaches have recently shown promise for improving spatial selectivity, but substantial design differences from conventional CIs will necessitate much additional safety and efficacy testing before clinical viability is established. Outside the cochlea, magnetic stimulation from small coils (micro-coils) has been shown to confine activation more narrowly than that from conventional microelectrodes, raising the possibility that coil-based stimulation of the cochlea could improve the spectral resolution of CIs. To explore this, we delivered magnetic stimulation from micro-coils to multiple locations of the cochlea and measured the spread of activation utilizing a multielectrode array inserted into the inferior colliculus; responses to magnetic stimulation were compared to analogous experiments with conventional microelectrodes as well as to responses when presenting auditory monotones. Encouragingly, the extent of activation with micro-coils was ~60% narrower compared to electric stimulation and largely similar to the spread arising from acoustic stimulation. The dynamic range of coils was more than three times larger than that of electrodes, further supporting a smaller spread of activation. While much additional testing is required, these results support the notion that magnetic micro-coil CIs can produce a larger number of independent spectral channels and may therefore improve auditory outcomes. Further, because coil-based devices are structurally similar to existing CIs, fewer impediments to clinical translational are likely to arise.

Funder

National Institutes of Health

Fondation Bertarelli

National Institute on Deafness and Other Communication Disorders

U.S. Department of Defense

BRAIN Initiative

Novo Nordisk Fonden

Remondi Foundation

Larry Bowman

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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