Pharyngeal Mechanosensory Neurons Control Food Swallow in Drosophila melanogaster

Author:

Qin Jierui12ORCID,Yang Tingting12,Li Kexin12,Liu Ting1,Zhang Wei12ORCID

Affiliation:

1. School of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University

2. Tsinghua-Peking Center for Life Sciences, Beijing

Abstract

As the early step of food ingestion, the swallow is under rigorous sensorimotor control. Nevertheless, the mechanisms underlying swallow control at a molecular and circuitry level remain largely unknown. Here, we find that mutation of the mechanotransduction channel genes nompC , Tmc, or piezo impairs the regular pumping rhythm of the cibarium during feeding of the fruit fly Drosophila melanogaster . A group of multi-dendritic mechanosensory neurons, which co-express the three channels, wrap the cibarium and are crucial for coordinating the filling and emptying of the cibarium. Inhibition of them causes difficulty in food emptying in the cibarium, while their activation leads to difficulty in cibarium filling. Synaptic and functional connections are detected between the pharyngeal mechanosensory neurons and the motor circuit that controls swallow. This study elucidates the role of mechanosensation in swallow, and provides insights for a better understanding of the neural basis of food swallow.

Publisher

eLife Sciences Publications, Ltd

Reference42 articles.

1. Biological pattern generation: The cellular and computational logic of networks in motion;Neuron,2006

2. Central pattern generators and the control of rhythmic movements;Curr Biol,2001

3. Biology of Drosophila, ed M Demerec (John Wiley & Sons;New York,1950

4. Motor neurons controlling fluid ingestion in Drosophila;Proc. Natl. Acad. Sci. USA,2012

5. Motor control of fly feeding;J. Neurogenet,2016

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