Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination-Reference-Cited by-同舟云学术

Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Published:2021-08-10 Issue: Volume:10 Page:
ISSN:2050-084X
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Author:

Jacob Christopher G¹,Thuy-Nhien Nguyen²,Mayxay Mayfong³⁴⁵,Maude Richard J⁵⁶⁷^ORCID,Quang Huynh Hong⁸,Hongvanthong Bouasy⁹,Vanisaveth Viengxay⁹,Ngo Duc Thang¹⁰,Rekol Huy¹¹,van der Pluijm Rob⁵⁶,von Seidlein Lorenz⁵⁶,Fairhurst Rick¹²,Nosten François⁵¹³^ORCID,Hossain Md Amir¹⁴,Park Naomi¹,Goodwin Scott¹,Ringwald Pascal¹⁵,Chindavongsa Keobouphaphone⁹,Newton Paul³⁵⁶,Ashley Elizabeth³⁵,Phalivong Sonexay³,Maude Rapeephan⁶¹⁶,Leang Rithea¹¹,Huch Cheah¹¹,Dong Le Thanh¹⁷,Nguyen Kim-Tuyen²,Nhat Tran Minh²^ORCID,Hien Tran Tinh²,Nguyen Hoa¹⁸,Zdrojewski Nicole¹⁸,Canavati Sara¹⁸,Sayeed Abdullah Abu¹⁴,Uddin Didar⁶,Buckee Caroline⁷^ORCID,Fanello Caterina I⁵⁶,Onyamboko Marie¹⁹,Peto Thomas⁵⁶,Tripura Rupam⁵⁶,Amaratunga Chanaki¹²,Myint Thu Aung⁵¹³,Delmas Gilles⁵¹³,Landier Jordi¹³²⁰^ORCID,Parker Daniel M¹³²¹,Chau Nguyen Hoang²,Lek Dysoley¹¹,Suon Seila¹¹,Callery James⁵⁶^ORCID,Jittamala Podjanee²²,Hanboonkunupakarn Borimas²²,Pukrittayakamee Sasithon²²²³,Phyo Aung Pyae⁵²⁴,Smithuis Frank⁵²⁴^ORCID,Lin Khin²⁵,Thant Myo²⁶,Hlaing Tin Maung²⁶,Satpathi Parthasarathi²⁷,Satpathi Sanghamitra²⁸,Behera Prativa K²⁸,Tripura Amar²⁹,Baidya Subrata²⁹,Valecha Neena³⁰,Anvikar Anupkumar R³⁰,Ul Islam Akhter³¹,Faiz Abul³²,Kunasol Chanon⁶,Drury Eleanor¹,Kekre Mihir¹,Ali Mozam¹,Love Katie¹,Rajatileka Shavanthi¹,Jeffreys Anna E³³,Rowlands Kate³³,Hubbart Christina S³³^ORCID,Dhorda Mehul⁵⁶³⁴,Vongpromek Ranitha⁶³⁴,Kotanan Namfon²²,Wongnak Phrutsamon⁶,Almagro Garcia Jacob³⁵,Pearson Richard D¹³⁵^ORCID,Ariani Cristina V¹,Chookajorn Thanat²²,Malangone Cinzia¹,Nguyen T¹,Stalker Jim¹,Jeffery Ben³⁵,Keatley Jonathan¹,Johnson Kimberly J¹³⁵,Muddyman Dawn¹,Chan Xin Hui S⁵⁶,Sillitoe John¹,Amato Roberto¹,Simpson Victoria¹³⁵,Gonçalves Sonia¹,Rockett Kirk¹³³^ORCID,Day Nicholas P⁵⁶^ORCID,Dondorp Arjen M⁵⁶^ORCID,Kwiatkowski Dominic P¹³⁵,Miotto Olivo¹⁶³⁵^ORCID

Affiliation:

1. Wellcome Sanger Institute, Hinxton, United Kingdom

2. Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam

3. Lao-Oxford-Mahosot Hospital-Wellcome Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic

4. Institute of Research and Education Development (IRED), University of Health Sciences, Ministry of Health, Vientiane, Lao People's Democratic Republic

5. Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

6. Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand

7. Harvard TH Chan School of Public Health, Harvard University, Boston, United States

8. Institute of Malariology, Parasitology and Entomology (IMPE-QN), Quy Nhon, Viet Nam

9. Centre of Malariology, Parasitology, and Entomology, Vientiane, Lao People's Democratic Republic

10. National Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Viet Nam

11. National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia

12. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, United States

13. Shoklo Malaria Research Unit, Mae Sot, Thailand

14. Chittagong Medical College Hospital, Chittagong, Bangladesh

15. World Health Organization, Geneva, Switzerland

16. Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

17. Institute of Malariology, Parasitology and Entomology (IMPEHCM), Ho Chi Minh City, Viet Nam

18. Vysnova Partners Inc, Hanoi, Viet Nam

19. Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

20. Aix-Marseille Université, INSERM, IRD, SESSTIM, Aix Marseille Institute of Public Health, ISSPAM, Marseille, France

21. Susan and Henry Samueli College of Health Sciences, University of California, Irvine, Irvine, United States

22. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

23. The Royal Society of Thailand, Bangkok, Thailand

24. Myanmar-Oxford Clinical Research Unit, Yangon, Myanmar

25. Department of Medical Research, Pyin Oo Lwin, Myanmar

26. Defence Services Medical Research Centre, Yangon, Myanmar

27. Midnapore Medical College, Midnapur, India

28. Ispat General Hospital, Rourkela, India

29. Agartala Medical College, Agartala, India

30. National Institute of Malaria Research, Indian Council of Medical Research, New Delhi, India

31. Ramu Upazila Health Complex, Cox's Bazar, Bangladesh

32. Malaria Research Group and Dev Care Foundation, Dhaka, Bangladesh

33. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

34. Worldwide Antimalarial Resistance Network (WWARN), Asia Regional Centre, Bangkok, Thailand

35. MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, United Kingdom

Abstract

Background:National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.Methods:Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs.Results:GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs.Conclusions:GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.Funding:The GenRe-Mekong project is funded by the Bill and Melinda Gates Foundation (OPP11188166, OPP1204268). Genotyping and sequencing were funded by the Wellcome Trust (098051, 206194, 203141, 090770, 204911, 106698/B/14/Z) and Medical Research Council (G0600718). A proportion of samples were collected with the support of the UK Department for International Development (201900, M006212), and Intramural Research Program of the National Institute of Allergy and Infectious Diseases.

Funder

Bill and Melinda Gates Foundation

Wellcome Trust

Medical Research Council

Department for International Development, UK Government

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/62997/elife-62997-v1.pdf

Reference43 articles.