1. National Yang Ming Chiao Tung University,Institute of Bioinformatics and Systems Biology,Hsinchu,Taiwan,300093
2. National Yang Ming Chiao Tung University,Institute of Biomedical Engineering,Hsinchu,Taiwan,300093
3. National Yang Ming Chiao Tung University,Institute of Electrical and Control Engineering, Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B),Hsinchu,Taiwan,300093
4. Kaohsiung Medical University,College of Medicine,Kaohsiung,Taiwan R.O.C.