Evaluation of the effectiveness of the use of a complex of antibacterial drugs for the treatment of bacterial hemorrhagic septicemia in fish

Author:

Romanova N. N.1,Myshkin A. V.1,Shchelkunova Yu. P.1,Tokareva S. B.1,Sekhina O. V.1,Kudinov P. V.1

Affiliation:

1. Branch for the freshwater fisheries of «VNIRO» («VNIIPRH»)

Abstract

The aim of the study was to develop therapeutic measures to combat bacterial hemorrhagic septicemia of fish using a complex of antibacterial drugs “Levofloxacin” and “Chlortetracycline”.Methods used: experiments were carried out in aquarium conditions on juvenile carp and hybrids «Siberian sturgeon×Kaluga» (hereinafter hybrid SO×K) infected with a mixed culture of pathogens: highly pathogenic strains of Aeromonas sp., strains of R.R. Acinetobacter and Citrobacter. In the experiment, 2 variants of the use of antibiotics for a course of 7 days were tested. Bacteriological seeding of fish parenchymal organ samples was carried out on nutrient and differential diagnostic media.Novelty: it consists in working out the scheme of application for fish of a complex of new antibiotics for aquaculture.Results: the results of the evaluation of the therapeutic effect of antibiotics “Levofloxacin” + “Chlortetracycline” in the treatment of bacterial hemorrhagic septicemia are presented. The cessation of fish death was noted the next day after the start of therapy. Positive results were obtained in carp — with a combination of levofloxacin at a dosage of 1000 mg/kg of ichthyomass and chlortetracycline — 100 mg/kg of ichthyomass, in a hybrid of SO×K — 500 mg/kg of ichthyomass of levofloxacin + 200 mg/kg of ichthyomass of chlortetracycline. Evaluation of their combinations with different dosages did not show 100% effect. The difficulties of therapy have been identified, which are associated with the spread of strains of microorganisms resistant to antibacterial drugs.Practical significance: the developed method of therapy is effective, reduces the damage from the disease and can be recommended when developing measures to combat bacterial hemorrhagic septicemia in fish in aquaculture.

Publisher

Russian Federal Research Institute of Fisheries and Oceanography

Reference19 articles.

1. Gavrilin K. V., Ridiger A. V., Ponomarev A. K. 2016. Rational chemotherapy of fish bacterioses in Russian aquaculture // Simvol nauki. № 2. P. 21-26. (In Russ.).

2. Golovin P.P., Golovina N.A., Romanova N.N. 2005. Inventory of medicinal products used and tested in aquaculture in Russia and abroad. Moscow: Rosinformagrotech. P. 56. (In Russ.).

3. Golovina N.A., Avdeeva E.V., Evdokimova E.B., Kazimirchenko O.V., Kotlyarchuk M. Yu. 2016. Workshop on ichthyopathology. Moscow: Morkniga. 417 p. (in Russ.).

4. Danilevskaya N.V. 2010. Features of the use of antibiotics in veterinary practice // Aktual’nye voprosy veterinarnoj biologii. № 3 (7). P. 37-41. (In Russ.).

5. Kundelekov A.G., Nefedov P.V., Kolycheva S.S. 2018. Lefokcin in medical practice // Sovremennye problemy nauki i obrazovaniya. № 5. (In Russ.).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3