Preparation and Evaluation of Sustained Release Microbeads Containing Ibuprofen

Abstract

The current study was carried out in order to prepare sustain release multiparticulate drug delivery system of Ibuprofen which is also known as 2-(4-isobutylphenyl) propionic acid. From the drug excipient study it was found that the drug and polymer were compatible with each other and there was no disappearance, new formation of peaks on the FTIR study. From the DSC study it was seen that there was no change in the melting point of drug when mixed with the polymers. The method applied was Ionotropic gelation. The Microbeads were prepared by employing sodium alginate as a coating agent with HPMC as release retardant and calcium chloride as a cross linking agent. The prepared microbeads were evaluated for various parameters such as micromertics, loose surface crystal study, percentage yield, percent cumulative drug release and surface morphology. From the various evaluated parameters it was revealed that the prepared microbeads were having a good flow property. The percentage yield was found to be in the range of 65.23% - 79.45%, the drug release was found to be in the range of 4.96% - 96.08%. The batch of B7 was the optimized one as it contain higher amount of drug content and shows better amount of drug release then the other batches. The surface morphology study revealed that the optimized formulation was having small cracks or fractures on the surface. From the study we can conclude that this method can be employed for preparing microbeads of Ibuprofen without any difficulty and this formulation can utilized for reducing the dose frequency of Ibuprofen which will not hinder the GIT.