In-situ Gel: A Novel Drug Delivery System

Abstract

The scientific community has been interested in gel-based systems, which have evolved during the ten years as a novel drug delivery strategy. A type of hydrogel called in-situ gels is a solution-based hydrogel that gels under a variety of physiological circumstances. Various elements, such as depend on the gel’s ability to form. Temperature variations, pH shifts, ion exposure, UV radiation, electrical sensitivity and a crucial enzyme from which the drug is delivered continually and in a controlled way are all factors that might affect the body. With continuing drug usage and long-term drug availability, they are intended to detoxify the substance. Reduced administration frequency provided by a controlled discharge pattern enhances patient compliance. Additionally, the drug’s dosage can be lowered and that the toxicity when compared to traditional treatment. In controlled drug delivery, the medication is given over an extended period of time with zero order kinetics, allowing for the measurement of plasma drug availability. The development of novels made of synthetic and natural polymers has advanced significantly. In modern life there are many benefits and uses of in-situ gelling systems. The review primarily focuses on an introduction to in-situ gel, its advantages and disadvantages, its mechanism, the mechanism of drug release from the system, different types of polymers used in formulations, typical preparation techniques and various types of in situ gels. Drug delivery applications for in-situ gel systems and in-situ gel testing.