Microsphere as Drug Delivery System: An Overview

Abstract

Microspheres are mainly free flowing powders consisting of proteins or synthetic polymers. Proteins or synthetic polymers are biodegradable in nature. Microspheres having a particle size less than 200 micrometer. Microspheres are novel drug delivery system which has several benefits over conventional multi dose therapy. There are various approaches in delivering a therapeutic agent to the specific targeted site in a sustained controlled release fashion. Microsphere is act as carriers for drugs. Microspheres received much attention for prolonged release as well as for targeting of anticancer drug to the tumour. In this drug delivery, drug dispersed throughout the particle i.e., the internal structure is a drug matrix and polymeric excipients. It is the reliable means delivery of the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. In future microspheres will find an appropriate place in novel delivery by combining various new strategies, particularly in diseased cell sorting, diagnostic, gene and genetic materials, safe, targeted and effective in vivo delivery. The current aim of this review is to study the various aspects of microspheres drug delivery system including advantages, disadvantages, types of microspheres, methods of preparations, Evaluations and Applications of microspheres.