Prediction of COVID-19 severity associated with Pneumonia by chest CT scan and Serological results

Abstract

Since 2019 December, a rapid increase in a cluster of Pneumonia cases has been identified in Wuhan, China. The novel Coronavirus infection has similar symptoms related to pneumonia. Initially, the virus replicates in the upper respiratory tract (cough and fever), and in most cases, the human immune system can fight it and defeat it. In moderate to severe cases, it infects the alveoli in the lungs (SOB) and causes a robust immune response (release of several cytokines, such as IL-6, IL-7, TNF-α that damage the tissue), that further worsens the disease condition to acute respiratory distress syndrome (ARDS), Pneumonia, and lung injury. In most cases, this requires ICU transfer and artificial ventilation. We studied the severity of the cases of COVID-19 associated with pneumonia. The serological tests, differential counts, and CT scans of 51 patients have been thoroughly observed and analyzed to determine these patients' mortality rates concerning their age. COVID-19 associated with pneumonia in older adults is fatal, associated with increased CRP (C reactive protein) levels, decreased lymphocytes, PCV/HCT, MCV. Our results suggest that the CT scans and serological parameters were found to be useful for clinicians in finding the severity of the COVID-19 associated with pneumonia in chronic phases, therapeutic decisions, and the disease prognosis