Synthesis of 1,3,4-Oxadiazole Derivatives with Its Antifungal Activity Evaluation

Author:

Patil Anuja S.1,Nikam Amit1,Mote Bhagyashree1,Ade Akshay1,Khot Vishal1,Sonawane Rushikesh1,Bagade Priyanka1

Affiliation:

1. Students of Rajarambapu College of Pharmacy, Kasegaon.

Abstract

Azole exhibits wide range of pharmacological properties. There is limited number of drugs are available to treat microbial infection that too have serious toxic effects the existing drugs has been suffering from the development of resistance and thus newer drugs are required with better activity profile. In this paper synthesis of 1,3,4- oxadiazole derivative with precursor salicylic acid and perform an antifungal activity.

Publisher

A and V Publications

Reference8 articles.

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2. Zoulikha Khiati, Adil.A. Othmun, Bettche Guessas. Synthesis and Antibacterial Activity of 1,3,4-Oxadiazole and 1,2,4-Triazole Derivative of Salicylic Acid and its Synthetic Intermediates. South African Journal of Chemistry. 2007 March 5, 60, 20-24.

3. Savithri Kumar, Basappa Chidananda, Vasantha Kumar. Crystal structure, Hirshfeld analysis and HSA interaction studies of N-[(E)-(5-bromothiophene-2-yl) methylidene]-3-hydroxynaphthalene-2-carbohydrazide. Journal of Molecular Structure. 2019 March 16, 1189,343-351.

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5. F. A. Omkar, N. M. Mahfouz and M. A. Rahaman. Synthesis and Antimicrobial Activity of 2-substituted [4-(1,3,4-oxadiazol-2-ylmethyl)] phthalazine-1 (2 H)-one Derivatives. European Journal Medicinal Chemistry. 1996, 31, 819-825.

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