Review on Vesicular Drug Delivery System: Aquasomes

Abstract

A special surface modification approach serves as a basis for a colloidal drug delivery system (CDDS) that helps to preserve the surface's constraining function. An aquasome is a submicronic structure (diameter 60-300nm). In order to create a medication delivery method other than liposome technology, they attracted a lot of attention in an effort to resolve issues with these vesicles' stability in biological fluids. Pharmaceuticals are absorbed by the aquasome, a molecular carrier made of a ceramic core (colloidal precipitation) to which glassy carbohydrates are subsequently permitted to adsorb as a nanometer-thick surface coating. Pharmaceuticals and other biochemically reactive surface members with non-covalently attached immobilized elements are stabilized by the carbohydrate coating, which also serves as a dehydroprotectant. These are nanoparticulate carrier systems but instead of being simple nanoparticles these are three layered self-assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. These structures are self-assembled by non-covalent and ionic bonds. A large number of In vitro and animal model studies have been used to investigate the physical characteristics of this enabling system. It can be used as a carrier for vaccinations, hemoglobin, medications, dyes, enzymes, and even genetic material, giving it a very broad range of applications.