Synthesis of 1,3,4-Oxadiazole derivatives with its Antifungal Activity Evaluation

Author:

Patil Anuja1,Shriniwas Mohite1

Affiliation:

1. Rajarambapu College of Pharmacy, Kasegoan.

Abstract

Azole exhibits wide range of pharmacological properties. there is limited number of drugs are available to treat microbial infection that too have serious toxic effects the existing drugs has been suffering from the development of resistance and thus newer drugs are required with better activity profile. In this paper synthesis of 1,3,4- oxadiazole derivative with precursor salicylic acid and perform an antifungal activity.

Publisher

A and V Publications

Reference8 articles.

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2. Zoulikha Khiati, Adil.A. Othmun, Bettche Guessas. Synthesis and Antibacterial Activity of 1,3,4-Oxadiazole and 1,2,4-Triazole Derivative of Salicylic Acid and its Synthetic Intermediates. South African Journal of Chemistry. 2007 March 5, 60, 20-24.

3. C. H. Lee, H. I. Cho and K-J. Lee. Synthesis of 1,3,4-oxadiazoles having phenol or thiophenol group. Bulletin of Korean Chemcal Society. 2001, 22, 10, 1153-1155.

4. Y. Zhang, R-Z. Qiao, P-F Xu, Z-Y Zang, Q. Wang. Synthesis and Antibacterial Activities of 2-(1-Aryl-5-Methyl-1,2,3-triazol-4yl)-1,3,4-0xadiazole derivatives. Journal of Chinese Chemical Society, 2013 September 24 ,49(3), 369-373.

5. B. H. Furniss, A. J. Hannaford, P. W. G. Smith and A. R. Tatchell, Vogel’s Text Book of Practical Organic Chemistry, Addison Wesley Longman, New Delhi (1998) p.1077.

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