Kinetics and Mechanism of Formation of 2,3-Disubstituted 1,4-Benzothiazines: One Pot DMSO Assisted Cyclocondensation of Bisanilino Disulphide and 1, 3-Dicarbonyls-Reference-Cited by-同舟云学术

Kinetics and Mechanism of Formation of 2,3-Disubstituted 1,4-Benzothiazines: One Pot DMSO Assisted Cyclocondensation of Bisanilino Disulphide and 1, 3-Dicarbonyls

Published:2021-09-28 Issue: Volume: Page:339-344
ISSN:0974-4150
Container-title:Asian Journal of Research in Chemistry
language:en
Short-container-title:AJRC

Author:

Sangvikar Meghmala R.¹,Phadnaik Gayatri M.²,Chavan Omprakash S.¹

Affiliation:

1. P.G., Department of Chemistry, Badrinarayan Barwale College, Jalna - 431213, Maharashtra, India and Affiliated to Dr. Babasaheb Ambedkar Marathwada University, Aurangabad.

2. Department of Chemistry, Institute of Science, Nagpur - 440012, Maharashtra, India and Affiliated to Rashtrasant Tukadoji Maharaj University, Nagpur.

Abstract

The kinetics of DMSO (dimethylsulphoxide) assisted one pot cyclocondensation of bisanilino disulphide and 1,3-dicarbonyls has been investigated using spectral method. The kinetic measurements have been carried by varying media, temperature and concentration of the reactants. The assistance of DMSO is investigated. The order of reaction, effects of substituents with dicarbonyls on the rates and thermodynamic parameters has also been reported. First time reaction conditions are optimised for performing the cyclocondensation conveniently and rapidly. Probably mechanism has been proposed and order of reaction was determined on the basis of rate expression and was in agreement with second order rate equation, used for the determination of rate constants.

Publisher

A and V Publications

Reference35 articles.

1. Finguelli R., Milanese L., Schiafella F., Role of 1,4-benzothiazine derivatives in medicinal chemistry. Mini Rev Med Chem. 2005; 5:1061-1673. doi: 10.2174/138955705774933365.

2. Erik De Clercq, Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for Intervention with HIV Infections. J. Med. Chem. 1995; 38(14):2491–2517. https://doi.org/10.1021/jm00014a001

3. Shamsuzzaman, Ayaz Mahmood Dar, Hena Khanam, Manzoor Ahmad Gatoo, Anticancer and antimicrobial evaluation of newly synthesized steroidal 5,6 fused benzothiazines. Arabian J. of Chem. 2014; 7:461-468. https://doi.org/10.1016/j.arabjc.2013.06.027.

4. Cecchetti V. C. Tabarrini O. and etal Sabatini S. Filipponi E. Testai, L. Spogli. R. Martinotti E. Fravolini A. Highly Potent 1,4-Benzothiazine Derivatives as KATP-Channel Openers. J. Med. Chem. 2003; 46:3670-3679. https://doi.org/10.1021/jm030791q.

5. Giuliano Grandolini, Luana Perioli, Valeria Ambrogi. Synthesis of some new 1,4-benzothiazine and 1,5-benzothiazepine tricyclic derivatives with structural analogy with TIBO and their screening for anti-HIV activity. Eur. J. Med. Chem. 1999; 34:701-709. https://doi.org/10.1016/S0223-5234(99)00223-8.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and genotoxic evaluation of a 4-(Oxiran-2-ylmethyl)-1,4-benzothiazin-3-one;Research Journal of Pharmacy and Technology;2022-11-24