Synthesis and Antimicrobial Activity of 5[(1, 3 dioxo-1, 3 dihydro-2H- isoindol-2-yl) methyl] - 2-hyroxy benzoic acid and their Metal Complexes

Abstract

The N- hydroxyl methyl phthalimide (HMP) is one of the organic products which has tendency to react phenolic derivative. While there are number of ligands are employed for the formation of phthalimide derivatives. Hence the present work has been undertaking with following objectives. The transition metal complexes (i.e. Cu+2, Co+2, Ni+2, Zn+2, Mn+2) of ligand 5[(1,3 dioxo- 1,3 dihydro-2H-isoindol 2-yl)methyl]-2-hydroxy benzoic acid have been determined. All the metal complexes were monitored for their antimicrobial activity. The plant pathogens were employed for this purpose. The results give these conclusions. All the complexes are toxic more or less to fungi. The substitution of phenyl rings does not have more effect on the fungicidal activity of chelates but in each series, the Cu-chelates have much toxicity. This is expected because the cupper salts are mostly used as fungicides. Most of the compounds inhibit the growth of above organisms which cause decease in many plants.