Affiliation:
1. YSPM’s Yashoda Technical Campus, Faculty of Pharmacy, Satara, 415003.
Abstract
In pharmaceutical industries there is possibilities of contamination, cross contamination, microbial contamination, adulteration of drug with other active ingredient or contamination with other material like raw material, dust, lubricant, intermediates and air born particle.1 Cleaning validation validate the effectiveness of cleaning procedure for removal of excipient, product residue, degradation product and cleaning agent. Cleaning validation improves the potency and reliability of cleaning in given pharmaceutical production and equipment. The cleaning validation is essential part of the quality assurance. As a result, validating cleaning procedures is critical in the pharmaceutical sector to ensure the safety, efficacy, and quality of drug batches. The purpose of this review is to provide information about cleaning validation in pharmaceutical industry to provide better customer care and quality of product. This article will discuss the relevance of cleaning validation in the pharmaceutical sector, and it will do so in accordance with regulatory guidelines.2,3
Reference34 articles.
1. Raj Pal G, Arya RKK, Joshi T, Bisht D. A review on cleaning validation in pharmaceutical industry, Journal of Drug Delivery and Therapeutics, 2018(8); 138-146.
2. Fauziya K, Abdul Sattar K, Nutan R. A review article on cleaning validation in Pharmaceutical industries IJRPC 2020, 10(2), 205- 214.
3. Prasanna Reddy Battu, MS Reddy. RP-HPLC Method for Simultaneous Estimation of Paracetamol and Ibuprofen in Tablets. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 70-72.
4. Murthy N and Chitra K. A review article on cleaning validation IJPSR, 2013.
5. Singh A, Sharma P. Simultaneous Development and Validation of Analytical Methods for Cleaning Samples Analysis of Gliclazide and Meslamine in Pharmaceutical Industry. Asian J. Research Chem. 2019; 12(6):326-329. doi: 10.5958/0974-4150.2019.00060.9