Complexation, Bio-evaluation, Magnetic Susceptibility and Thermodynamic study of Newly Synthesized Pharmacologically active Schiff base with La(III), Ce(III) and Sm(III)

Abstract

Present research work describes the successful development of inner transition metal ion complexation, magnetic susceptibility study, thermodynamic parameters and biological applications of synthesized organic ligand. Stability constant Order of developed metal complexes of N-[-(4-chlorophenyl) methylene] isonicotinohydrazide was found as follows La(III) > Ce(III) > Sm(III). Positive μeff clearly indicates paramagnetic nature of developed complexes. During thermodynamic parameter examination we found stability constants for complexes decrease with an increasing temperature, indicating that the composition equilibrium is exothermic in nature. Also ΔH and ΔG were negative for all of the systems which suggested that all of the reactions were exothermic. The ΔS found positive for most of the complexes which indicate in metal-ligand binding process is entropy favourable. In antimicrobial evaluation, we observed that Sm+3 metal complexes of (N-[(E)-(4-chlorophenyl) methylene] isonicotinohydrazde) exhibit superior property specifically against gram negative bacteria with respect to organic ligand.