Affiliation:
1. Department of Chemistry, Mathuradas Mohota College of Science, Nagpur, Maharashtra.
Abstract
The pharmaceutical cocrystals have sparked a lot of attention because of their ability to improve a drug’s physicochemical flaws, like poor water solubility. The amino carboxylic derivative of benzene was used to synthesized the benzocaine-based compounds which shows numerous biological activities. Here the mechanochemical solvent assisted grinding method were used to obtain the benzocaine-based co-crystals which is not reported yet before. The synthesized benzocain co-crystals were further analyzed using P-XRD and FTIR spectroscopic techniques. The shifting of IR peak from its individual compounds are clearly confirm the formation of co-crystal. From P-XRD analysis it is confirms that the benzocain compound and coformer shows different phase compare to its co-crystal which give the confirmation of co-crystal formation. The formation of co-crystals was further supported by taking their melting point which is completely different than pure component and its co-former. The Cambridge Structural Database (CSD) survey were used for structural analysis of reported benzocaine using mercury software. The crystal explorer software were used to calculate the percentage bond interactions in the reported benzocaine compound.
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