Simple Colourimetric Method and Development of A Colour Kit for on-the-spot Azelnidipine Estimation using A Smartphone Application, with Comparison to the UV-Spectroscopic Method

Author:

Suthar Pallavi1,Mashru Rajshree2

Affiliation:

1. Assistant Professor, Shree Swaminarayan Sanskar Pharmacy Collage, Zundal, Gujarat.

2. Professor, The Maharaja Sayajirao University of Baroda, Vadodara, Gujart.

Abstract

In the proposed research paper, a simple and accurate colorimetric method has been developed for the estimation of Azelnidipine in bulk. Instead of a traditional UV spectrophotometer, the proposed method measures the colour intensity of a solution using a smartphone camera and an application. This colorimetric method was found to be linear in the concentration range of 2µg/ml to 10µg/ml with an r2 value of 0.9993. The limits of detection (LOD) and quantification (LOQ) were found to be 0.024µg/ml and 0.068µg/ml, respectively.

Publisher

A and V Publications

Reference10 articles.

1. https://pubchem.ncbi.nlm.nih.gov/compound/Azelnidipine

2. Rele RV, Patil SP. Ultra-Violet Spectrophotometric Method for Estimation of Azelnidipine from Bulk Drug and Pharmaceutical Formulation. Asian Journal of Research in Chemistry. 2010; 3(4): 1077-9

3. Mandale D, Mistry R, Chauhan N. An analytical approach of azelnidipine: a review. Muralidharan S, S. Parasuraman and V. Venugopal, Simple Validation of Azelnidipine By RP-HPLC Method. Rapports De Pharmacie. 2015; 1(1): 43-45.

4. Raskapur KD, Patel MM, Captain AD. UV-Spectrophotometric method development and validation for determination of Azelnidipine in pharmaceutical dosage form. Toxicology. 2010; 106: 135-43.

5. Shewale VU, et al. Azelnidipine: A Review on Therapeutic Role in Hypertension. Journal of Drug Delivery and Therapeutics. 2019; 9: 1002-1005.

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