Natural Therapeutics against the SARS-CoV-2 Viral infection

Abstract

Coronaviruses are a class of large, enveloped, positive-sensed, single-stranded RNA viruses that cause infections in the respiratory tracts of mammals such as humans, bats, and other animals. Coronavirus disease 2019 (COVID-19), also known as 2019 new coronavirus (2019-nCoV), is an agile respiratory disease caused by a novel coronavirus that was first discovered in Wuhan, China. It has now expanded to 216 nations and killed over 0.5 million people worldwide, prompting the World Health Organization (WHO) to proclaim it a pandemic. Current review focuses on the role of herbs and herbs-derived secondary metabolites in inhibiting the SARS-CoV-2 virus as well as in the management of post-COVID-19 complications. This strategy will promote and protect the use of medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been shown to prevent viral infection and to alleviate post-COVID complications such as parkinsonism, kidney and heart failure, liver and lung damage, and mental problems. We investigated mechanistic approaches of herbal medicines and their phytochemicals as antiviral and post-COVID complications by modulating immunological and inflammatory states in this review.