Influence of Newly Synthesized Superdisintegrant on Dissolution Rate Enhancement of Carbamazepine using Liquisolid Compact Technique

Abstract

The purpose of this study was to manufacture liquisolid compact of high dose poorly water-insoluble drug, Carbamazepine (CBZ) by using novel superdisintegrant for the purpose of fast disintegration and improved its dissolution rate. The solubility of CBZ was analyzed in various non-volatile solvents in order to find the vehicle with the maximum solubility. The dissolving profile of liquisolid compacts was compared to a marketed tablet formulation's dissolution profile. CBZ was found to be much more soluble in polyethylene glycol 200 than in the other solvents. Crosspovidone-containing formulations showed no disintegration, but all other formulations disintegrated after 91.2 seconds. A Starch Glutamate-Croscarmellose Sodium combination has a disintegration time of 42.5 seconds. The optimized batch NSC1 including Starch Glutamate-Croscarmellose Sodium had 94.81 % greater drug release compared to the marketed formulation. This investigation found that the novel superdisintegrant had the fastest disintegration and the highest drug release compared to other disintegrants.