Formulation Development and Evaluation Nefidipine Loaded Ethosomal Gel for Transdermal Drug Delivery-Reference-Cited by-同舟云学术

Formulation Development and Evaluation Nefidipine Loaded Ethosomal Gel for Transdermal Drug Delivery

Published:2023-06-03 Issue: Volume: Page:77-80
ISSN:2231-5691
Container-title:Asian Journal of Pharmaceutical Research
language:en
Short-container-title:AJPR

Author:

Sirisha Y.¹,Sriram Buddarthi¹,Sri S Ramya²

Affiliation:

1. Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad - 501301, Telangana, India.

2. Department of Pharmacy, University College of Technology, Osmania University, Hyderabad - 500007, Telangana, India.

Abstract

In the present investigation efficiency of ethosomes as novel lipid carriers for topical delivery of Nifedipine has been evaluated. Ethosomes were optimized by varying concentration of Lecithin and ethanol. Ethosomal formulation (NE6) with Lecithin (50mg) and ethanol 20mL was optimized. On characterization spherical, unilamellar vesicles with smooth surface were observed under scanning electron microscopy (SEM). Zeta potential of NE6 formulation was found to be -32.55mv. Drug entrapment efficiency of NE6 formulation was found to be 97.63%. The optimized formulation exhibited pH (5.8) and viscosity (42299cps). Physical evaluation of ethosomal gel was done. In vitro release of NE6 formulation was carried out which showed 94.34% release over a period of 24hours. From the data obtained after plotting various models it was observed that the Peppas model was found to be best suited with R2 value of 0.974. Results suggested that ethosomes as efficient carriers for Nifedipine topical delivery.

Publisher

A and V Publications

Reference12 articles.

1. Vijay Singh Jatav, Jitendra Singh Saggu, Ashish Kumar Sharma, Santosh Kumar Singh. Effect of Dimethyl Sulphoxides as Permeation Enhancer on Transdermal Patch of Nebivolol Hydrochloride. Asian J. Res. Pharm. Sci. 3(1): Jan.-Mar. 2013; Page 08-11.

2. Jatav Vijay Singh, Saggu Jitendra Singh, Sharma Ashish Kumar, Gilhotra Ritu Mehra, Sharma Anil, Jat Rakesh Kumar. Design, Formulation and in vitro Drug Release from Transdermal Patches containing Nebivolol Hydrochloride as Model Drug. Asian J. Pharm. Res. 2(4): Oct. - Dec. 2012; Page 136-141.

3. Muskan M. Maniyar, Amol S. Deshmukh, Suvarna J. Shelke. Ethosomes: A carrier for Transdermal Drug Delivery System. Asian Journal of Pharmaceutical Research. 2022; 12(3):225-8. doi: 10.52711/2231-5691.2022.00037

4. R.B. Saudagar, S. Samuel. Ethosomes: Novel noninvasive carrier for Transdermal Drug Delivery. Asian J. Pharm. Tech. 2016; 6(2): 135-138. doi: 10.5958/2231-5713.2016.00019.2

5. Roge Ashish B, Sakhare Ram S, Bakal RL, Channawar MA, Bakde BV, Gawande SR , Chandewar AV. Ethosomes: Novel Approach in Transdermal Drug Delivery System. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):23-27.