Metoprolol succinate sustained release tablet: A review

Abstract

The main Purpose of existing investigation is to formulate and evaluate the sustained released tablet of Metoprolol Succinate using different polymer. Metoprolol Succinate is a β1-adrenergic receptor antagonist employed as an anti-arrhythmic, antianginal, antihypertensive. These content 99.0% to 101.0% (dried substance) appearance of Metoprolol Succinate is white or almost white, crystalline powder. Prolonged release tablet of Metoprolol Succinate were developed employing polymers. The globe is now becoming more and more interested in natural medications and excipients. The fact that these natural materials are chemically inert, nontoxic, less expensive, biodegradable, and readily accessible gives them several advantages over synthetic ones. Due to their excellent water-swellability, non-toxicity, low cost, and free availability, gums and mucilages are intriguing polymers for the creation of medicinal formulations. Gums and mucilages find applications in tablet formula as binders due to their adhesive nature. They impart cohesiveness to the powder mass and convert them into granules, which are further compressed into tablets.