Design, Development and Evaluation of Thiocolchicoside and Famotidine Agglomerates by Crystallo Co-Agglomeration Technique

Abstract

Thiocolchicoside and Famotidine are both have known to be used in joint pain or in the treatment of rheumatoid arthritis, etc. But the problem arises in the bioavailability and absorption of these drugs in the body. The current study deals with the design and evaluation of crystal co-agglomerates prepared with the use of various concentration of polymers like HPMC K15M and PVA. The aim of the study was to improvise the flow property, wettability, and dissolution property of the drug and to enhance its absorption in the body which will give better therapeutic response. The prepared co-agglomerates were evaluated for the parameters and it was found that the F4 bath was optimum because better flow ability, maximum drug content and increased dissolution property. SEM study shows the clear cylindrical crystals formed and the stability study shows that the prepared co-agglomerates were stable for the period of time without any significant change in the preparation. It was concluded that the preparation of crystal co-agglomerates was a successful approach in improving the various properties which can reduce the chances of metabolism of drug and will give better therapeutic response and stability of the drug.