Floating Drug Delivery System: An Overview

Author:

Bindu A.V.S. Hima1,Bhavya G.1,Padmalatha K.2

Affiliation:

1. Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada - 521108.

2. Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada - 521108.

Abstract

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The recent developments in floating drug delivery systems are containing the physiological and formulation variables impacting on gastric retention time, approaches to formulating of single-unit and multiple-unit floating systems, and their classification and formulation aspects are discussed in detail. This review also summarizes evaluation parameters and application of floating drug delivery systems.

Publisher

A and V Publications

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Floating Drug Delivery System: A Novel apporach for Delivery of Drug on Targated Organ;Research Journal of Pharmaceutical Dosage Forms and Technology;2022-11-12

2. Natural Polymer Based Floating Matrix Tablets of Domperidone;Research Journal of Pharmaceutical Dosage Forms and Technology;2022-11-12

3. Formulation and characterization of nimodipine in situ gels for oral delivery;International journal of health sciences;2022-04-22

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