Evaluation of Hypoglycemic potential of Moringa oleifera bark extracts on normal and Alloxanized diabetic rats

Abstract

Diabetes Mellitus is a leading community health agony. Although steady new drug evolution to care intended for diabetes, herbal remedy stay a prospective add-on remedy to maintain glucose level in the body. Moringa oleifera (Moringaceae) has been conventionally used to deal with numerous diseases as the anti-oxidant properties it reports. The effect M. oleifera stem bark extracts against diabetes alloxanized diabetic rats were employed in this research. Bark of M. oleifera stem was used. Male Wistar albino rats (150–200g) were employed. Blood samples were accumulated by retro-orbital plexus puncture method and blood glucose of all animals was examined by means of an electronic glucometer. Diabetes commences due to Alloxan during its capability to demolish the insulin-generating beta cells of the pancreas. Three weeks observations indicate drop in blood glucose levels as in Alloxan + glibenclamide (10mg/kg) used as standard from 295mg/dl to 149mg/dl. Alloxan + Methanolic extract of M. oleifera (100mg/kg) from 294 mg/dl to 237mg/dl. Alloxan + Methanolic extract of M. oleifera (200mg/kg) from 295mg/dl to 232mg/dl. Alloxan + Methanolic extract of M. oleifera (400 mg/kg) from 290mg/dl to 229mg/dl. Three weeks of daily treatment of extract of M. oleifera led to a dose dependent fall in blood sugar in three weeks for methanolic extract of M. oleifera. The current research concludes that extracts of M. oleifera bark is able to demonstrate drop in blood glucose level in normal and alloxan treated rats.