Effective Management of Rare Lymphangioleiomyomatosis Using Sirolimus: Tablet Matrix with Hibiscus rosa sinensis Leave Mucilage

Abstract

The authors aimed to extend the discharge of Sirolimus from the tablets with a blend of herbal and synthetic polymers. In this study, Sirolimus was taken as a model drug, Hydroxy Propyl Methyl Cellulose as a synthetic polymer and mucilage from Hibiscus rosa sinensis leaves as a natural polymer. Sirolimus is an orphan drug used to treat Lymphangioleiomyomatosis damage and to suppress body refuse towards the transplanted organs. Sirolimus matrix tablets made with the blend of Hibiscus rosa sinensis leaves mucilage and Hydroxy Propyl Methyl Cellulose. The blend was assessed for flow possessions and the designed tablets were categorized for official and non-official tests including Sirolimus discharge. The Sirolimus matrix tablets possess good Sirolimus content with passible pre and post-formulation parameters. The study concludes that there were no chemical interactions between Sirolimus with polymers used. The study also revealed that Hibiscus rosa sinensis leaves mucilage can be a good polymer in grouping with other polymers for prolonged drug discharge.