A Review on Traditional uses, Bioactive Chemical Constituents, Pharmacology, and Toxicity of Tinospora cordifolia (Guduchi or Giloy)

Abstract

Traditional medicine is a body of knowledge, skills, and practices based on traditional cultures' presumptions, beliefs, and experiences in order to maintain their health. Traditional herbal treatments are highly valued among many rural or indigenous people in many underdeveloped nations. According to the World Health Organization, about 80% of the world's population relies on traditional medicine, with 60% of rural Indians using herbal treatments. During the previous five years, utilization of herbal supplements grew from 2.5% to 12percent. Tinospora cordifolia is a member of the Menispermaceae family and possesses a wide range of immunotherapeutic qualities, including antipyretic, anti-inflammatory, antiallergic, antidiabetic, antihepatotoxic, and antibacterial activities, as well as relatively low toxicity. Tinospora cordifolia (Guduchi), a perennial and climbing shrub with succulent stems and papery barks, is found all over the world. It has been discovered that the leaf extract is beneficial in treating infections caused by B. subtilis, P. vulgaris, S. aureus, E. coli, and S. pyrogens. Furthermore, it supports the process of cell renewal and repair. The plant is used to make herbal medicines on a yearly basis in about 10,000 tonnes. Phenyl propanoid glycosides like Syringin, Cordifolioside A, and Cordifolioside B, as well as the immunostimulatory molecule d-glucan, are among the main active substances identified from the plant. Tannins, alkaloids, carbohydrates, terpenoids, steroids, flavonoids, and phenols are some of the chemical components found in medicinal plants that have a distinct physiological effect on the human body. Medicinal plants do not only exhibit natural therapeutic properties, but also provide natural prevention against various diseases. As a result, we are attempting to summarize, gather the number of plants, and their ethnopharmacological qualities in this complete review study research.